Deflazacort in comparison to other steroids for nephrotic syndrome

Comparison of Daily versus Every Other Day Treatment Regimen of Levamisole to Control Recurrence in the Childhood Idiopathic Nephrotic Syndrome

Background Idiopathic nephrotic syndrome is a kidney involvement that causes edema and heavy proteinuria with severe complications if the treatment is started late. The present study aimed to assess the efficacy of Levamisole in the daily versus every other day treatment regimen to control recurrence in Childhood Idiopathic Nephrotic Synd...

Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome

Toxic epidermal necrolysis (TEN) is a drug-related fatal disease. Extensive necrosis of the epidermis can lead to serious complications. This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lo...

Steroids in Treatment of the Nephrotic Syndrome in Adults.

Deflazacort Versus Prednisolone: Randomized Controlled Trial in Treatment of Children With Idiopathic Nephrotic Syndrome

BACKGROUND Corticosteroids are the main therapy of nephrotic syndrome and goal of corticosteroid therapy is to obtain maximum clinical benefit with minimum adverse effects. Children are more vulnerable to side effects of corticosteroids related to growth and adrenal suppression, so a search for an alternative steroid with fewer side-effects is underway. Deflazacort is an oxazoline derivative an...

Simvastatin in nephrotic syndrome. Simvastatin in Nephrotic Syndrome Study Group.

BACKGROUND Hyperlipidemia of the nephrotic syndrome is a risk factor for the development of systemic atherosclerosis, but it also may aggravate glomerulosclerosis and enhance the progression of glomerular disease. HMG-CoA reductase inhibitors are effective in reducing cardiovascular morbidity and mortality. Whether they may influence the progression of glomerular disease is not clear. The Simva...